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Article

Leucine-Rich Repeat Kinases.

Annual review of biochemistry - 1 Aug 2024

Alessi Dario R, Pfeffer Suzanne R

Abstract excerpt

Activating mutations in leucine-rich repeat kinase 2 (LRRK2) represent the most common cause of monogenic Parkinson's disease. LRRK2 is a large multidomain protein kinase that phosphorylates a specific subset of the ∼65 human Rab GTPases, which are master regulators of the secretory and endocytic pathways. After phosphorylation by LRRK2, Rabs lose the capacity to bind cognate effector proteins and guanine...

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Source

Identifiers

PMID: 38621236
DOI: 10.1146/annurev-biochem-030122-051144

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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