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Article

LRRK2 mediates tubulation and vesicle sorting from lysosomes.

Science advances - 1 Nov 2020

Bonet-Ponce Luis, Beilina Alexandra, Williamson Chad D, Lindberg Eric, Kluss Jillian H, Saez-Atienzar Sara, Landeck Natalie, Kumaran Ravindran, Mamais Adamantios, Bleck Christopher K E, Li Yan, Cookson Mark R

Abstract excerpt

Genetic variation around the LRRK2 gene affects risk of both familial and sporadic Parkinson's disease (PD). However, the biological functions of LRRK2 remain incompletely understood. Here, we report that LRRK2 is recruited to lysosomes after exposure of cells to the lysosome membrane-rupturing agent LLOME. Using an unbiased proteomic screen, we identified the motor adaptor protein JIP4 as an LRRK2 partner at the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33177079
DOI: 10.1126/sciadv.abb2454
PMCID: PMC7673727

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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