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Article

The Role of LRRK2 in Intracellular Organelle Dynamics.

Journal of molecular biology - 15 Jun 2023

Boecker C Alexander

Abstract excerpt

Pathogenic mutations in the leucine-rich repeat kinase 2 (LRRK2) gene hyperactivate LRRK2 kinase activity and lead to the development of Parkinson's disease (PD). Membrane recruitment of LRRK2 and the identification of RAB GTPases as bona fide LRRK2 substrates strongly indicate that LRRK2 regulates intracellular trafficking. This review highlights the current literature on the role of LRRK2 in intracellular...

Topics

Humans
Autophagy
Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
Lysosomes
Mutation
Parkinson Disease
rab GTP-Binding Proteins

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 36764357
DOI: 10.1016/j.jmb.2023.167998

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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The Role of LRRK2 in Intracellular Organelle Dynamics.PMID 36764357Read ↗

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LRRK2 at the Crossroad Between Autophagy and Microtubule TraffickingSemantic proximity Read ↗

Cellular functions of LRRK2 implicate vesicular trafficking pathways in Parkinson's disease.Semantic proximity Read ↗

Mechanisms of lysosomal tubulation and sorting driven by LRRK2.Semantic proximity Read ↗

LRRK2, a puzzling protein: insights into Parkinson's disease pathogenesis.Semantic proximity Read ↗

LRRK2 Biology from structure to dysfunction: research progresses, but the themes remain the same.Semantic proximity Read ↗

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