Article
Rab12 is a regulator of LRRK2 and its activation by damaged lysosomes.
eLife - 24 Oct 2023
Wang Xiang, Bondar Vitaliy V, Davis Oliver B, Maloney Michael T, Agam Maayan, Chin Marcus Y, Cheuk-Nga Ho Audrey, Ghosh Rajarshi, Leto Dara E, Joy David, Calvert Meredith E K, Lewcock Joseph W, Di Paolo Gilbert, Thorne Robert G, Sweeney Zachary K, Henry Anastasia G
Abstract excerpt
Leucine-rich repeat kinase 2 (LRRK2) variants associated with Parkinson's disease (PD) and Crohn's disease lead to increased phosphorylation of its Rab substrates. While it has been recently shown that perturbations in cellular homeostasis including lysosomal damage can increase LRRK2 activity and localization to lysosomes, the molecular mechanisms by which LRRK2 activity is regulated have remained poorly...
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