Article

Rab12 regulates LRRK2 activity by promoting its localization to lysosomes

2023-02-22

Abstract excerpt

Leucine-rich repeat kinase 2 (LRRK2) variants associated with Parkinson’s disease (PD) and Crohn’s disease lead to increased phosphorylation of its Rab substrates. While it has been recently shown that perturbations in cellular homeostasis including lysosomal damage and stress can increase LRRK2 activity and localization to lysosomes, the molecular mechanisms by which LRRK2 activity is regulated have remained poor...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c6ff4860-7fbf-5824-8ae1-7203b3e952fa
DOI: 10.1101/2023.02.21.529466

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Rab12 regulates LRRK2 activity by promoting its localization to lysosomesDOI 10.1101/2023.02.21.529466Read

Rab12 is a regulator of LRRK2 and its activation by damaged lysosomes.Semantic proximity Read

LRRK2 kinase dependent and independent function on endolysosomal repair promotes macrophage cell deathSemantic proximity Read

Accumulation of LRRK2-associated phospho-Rab12 degenerative lysosomes in tauopathiesSemantic proximity Read

Genome-wide screen reveals Rab12 GTPase as a critical activator of Parkinson's disease-linked LRRK2 kinase.Semantic proximity Read

RAB12-LRRK2 Complex Suppresses Primary Ciliogenesis and Regulates Centrosome Homeostasis in AstrocytesSemantic proximity Read

Genome-wide screen reveals Rab12 GTPase as a critical activator of pathogenic LRRK2 kinaseSemantic proximity Read

LRRK2 kinase-mediated accumulation of lysosome-associated phospho-Rabs in tauopathies and synucleinopathies.Semantic proximity Read

RAB12-LRRK2 complex suppresses primary ciliogenesis and regulates centrosome homeostasis in astrocytes.Semantic proximity Read

Lysosomal positioning regulates Rab10 phosphorylation at LRRK2+ lysosomes.Semantic proximity Read

Lysosomal positioning regulates Rab10 phosphorylation at LRRK2-positive lysosomesSemantic proximity Read

The G2019S variant of leucine-rich repeat kinase 2 (LRRK2) alters endolysosomal trafficking by impairing the function of the GTPase RAB8ASemantic proximity Read

Elucidating the molecular interplay between LRRK2 and Rab GTPasesSemantic proximity Read