Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Lysosomal positioning regulates Rab10 phosphorylation at LRRK2+ lysosomes.

Proceedings of the National Academy of Sciences of the United States of America - 25 Oct 2022

Kluss Jillian H, Beilina Alexandra, Williamson Chad D, Lewis Patrick A, Cookson Mark R, Bonet-Ponce Luis

Abstract excerpt

Genetic variation at the leucine-rich repeat kinase 2 (LRRK2) locus contributes to an enhanced risk of familial and sporadic Parkinson's disease. Previous data have demonstrated that recruitment to various membranes of the endolysosomal system results in LRRK2 activation. However, the mechanism(s) underlying LRRK2 activation at endolysosomal membranes and the cellular consequences of these events are still poorly...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Leucine
Share to Leucine-Rich Repeat Serine-Threonine Protein Kinase-2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lysosomes

Share to Mutation

Share to Phosphoric Monoester Hydrolases

Share to Phosphorylation

Share to rab GTP-Binding Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 36256825
DOI: 10.1073/pnas.2205492119
PMCID: PMC9618077

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Lysosomal positioning regulates Rab10 phosphorylation at LRRK2+ lysosomes.PMID 36256825Read ↗

Lysosomal positioning regulates Rab10 phosphorylation at LRRK2-positive lysosomesSemantic proximity Read ↗

Roles of the Drosophila LRRK2 homolog in Rab7-dependent lysosomal positioning.Semantic proximity Read ↗

Rab12 is a regulator of LRRK2 and its activation by damaged lysosomes.Semantic proximity Read ↗

LRRK2 mediates tubulation and vesicle sorting from lysosomes.Semantic proximity Read ↗

Opposing actions of JIP4 and RILPL1 provide antagonistic motor force to dynamically regulate membrane reformation during lysosomal tubulation/sorting driven by LRRK2Semantic proximity Read ↗

Rab12 regulates LRRK2 activity by promoting its localization to lysosomesSemantic proximity Read ↗

Mechanisms of lysosomal tubulation and sorting driven by LRRK2.Semantic proximity Read ↗

LRRK2 at the interface of autophagosomes, endosomes and lysosomes.Semantic proximity Read ↗

LRRK2 mediates tubulation and vesicle sorting from membrane damaged lysosomesSemantic proximity Read ↗

Leucine-Rich Repeat Kinases.Semantic proximity Read ↗

The Role of LRRK2 in Intracellular Organelle Dynamics.Semantic proximity Read ↗

Cellular functions of LRRK2 implicate vesicular trafficking pathways in Parkinson's disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.