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Article

Roles of the Drosophila LRRK2 homolog in Rab7-dependent lysosomal positioning.

Human molecular genetics - 15 Mar 2012

Dodson Mark W, Zhang Ting, Jiang Changan, Chen Shengdi, Guo Ming

Abstract excerpt

LRRK2 (PARK8) is the most common genetic determinant of Parkinson's disease (PD), with dominant mutations in LRRK2 causing inherited PD and sequence variation at the LRRK2 locus associated with increased risk for sporadic PD. Although LRRK2 has been implicated in diverse cellular processes encompassing almost all cellular compartments, the precise functions of LRRK2 remain unclear. Here, we show that the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22171073
DOI: 10.1093/hmg/ddr573
PMCID: PMC3284123

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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