Article

LRRK2 mediates tubulation and vesicle sorting from membrane damaged lysosomes

2020-01-24

Abstract excerpt

<h4>ABSTRACT</h4> Mutations in the leucine rich repeat kinase 2 ( LRRK2 ) gene are a cause of familial and sporadic Parkinson’s disease (PD). Nonetheless, the biological functions of LRRK2 remain incompletely understood. Here, we observed that LRRK2 is recruited to lysosomes that have a ruptured membrane. Using unbiased proteomics, we observed that LRRK2 is able to recruit the motor adaptor protein JIP4 to perme...

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Literature Corpus work: 434c7e83-2c83-5c12-bc4a-abfea42e3dd2
DOI: 10.1101/2020.01.23.917252

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