Article

Opposing actions of JIP4 and RILPL1 provide antagonistic motor force to dynamically regulate membrane reformation during lysosomal tubulation/sorting driven by LRRK2

2024-04-03

Abstract excerpt

<h4>ABSTRACT</h4> Lysosomes are dynamic cellular structures that adaptively remodel their membrane in response to stimuli, including membrane damage. We previously uncovered a process we term LYTL (LYsosomal Tubulation/sorting driven by Leucine-Rich Repeat Kinase 2 [LRRK2]), wherein damaged lysosomes generate tubules sorted into mobile vesicles. LYTL is orchestrated by the Parkinson’s disease-associated kinase LR...

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Literature Corpus work: 9876cbf8-78fc-53d5-a1f8-57381ba84b3a
DOI: 10.1101/2024.04.02.587808

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