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Article

Different posterior hippocampus and default mode network modulation in young APOE ε4 carriers: a functional connectome-informed phenotype longitudinal study.

Molecular neurobiology - 1 Jun 2021

Zheng Li Juan, Lin Li, Schoepf U Joseph, Varga-Szemes Akos, Savage Rock H, Zhang Han, Wang Yun Fei, Zhang Xin Yuan, Luo Song, Liu Ya, Yang Gui Fen, Lu Guang Ming, Zhang Long Jiang

Abstract excerpt

To determine the functional connectome change pattern based on subregions of the hippocampus in young APOEε4 carriers during a 3-year follow-up. All the participants (n = 213) were tested for resting-state functional MRI, neuropsychological scales, and APOE genotype. The age- and sex-matched APOE ε4/ε3 (23.9 ± 3.2 years old, 6 female/7 male) carriers and APOE ε3/ε3 (22.9 ± 1.6 years old, 7 female/12 male)...

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PMID: 33496907
DOI: 10.1007/s12035-021-02292-2

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