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Article

APOE-ε4 Shapes the Cerebral Organization in Cognitively Intact Individuals as Reflected by Structural Gray Matter Networks.

Cerebral cortex (New York, N.Y. : 1991) - 1 Jun 2020

Cacciaglia Raffaele, Molinuevo José Luis, Falcón Carles, Arenaza-Urquijo Eider M, Sánchez-Benavides Gonzalo, Brugulat-Serrat Anna, Blennow Kaj, Zetterberg Henrik, Gispert Juan Domingo

Abstract excerpt

Gray matter networks (GMn) provide essential information on the intrinsic organization of the brain and appear to be disrupted in Alzheimer's disease (AD). Apolipoprotein E (APOE)-ε4 represents the major genetic risk factor for AD, yet the association between APOE-ε4 and GMn has remained unexplored. Here, we determine the impact of APOE-ε4 on GMn in a large sample of cognitively unimpaired individuals, which was...

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Identifiers

PMID: 32163130
DOI: 10.1093/cercor/bhaa034
PMCID: PMC7264689

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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