Article
Brain network local interconnectivity loss in aging APOE-4 allele carriers.
Proceedings of the National Academy of Sciences of the United States of America - 20 Dec 2011
Brown Jesse A, Terashima Kevin H, Burggren Alison C, Ercoli Linda M, Miller Karen J, Small Gary W, Bookheimer Susan Y
Abstract excerpt
Old age and possession of the APOE-4 allele are the two main risk factors for developing later onset Alzheimer's Disease (AD). Carriers of the APOE-4 allele have known differences in intrinsic functional brain network activity across the life span. These individuals also demonstrate specific regional differences in gray and white matter gross structure. However, the relationship of these variations to whole brain...
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