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Article

APOE4 enhances age-dependent decline in cognitive function by down-regulating an NMDA receptor pathway in EFAD-Tg mice.

Molecular neurodegeneration - 5 Mar 2015

Liu De-shan, Pan Xiao-dong, Zhang Jing, Shen Hui, Collins Nicole C, Cole Arron M, Koster Kevin P, Ben Aissa Manel, Dai Xiao-man, Zhou Meng, Tai Leon M, Zhu Yuan-gui, LaDu Mary, Chen Xiao-chun

Abstract excerpt

BACKGROUND: Alzheimer's disease (AD) causes progressive loss of memory and cognition, exacerbated by APOE4, the greatest genetic risk factor for AD. One proposed mechanism for apolipoprotein E (apoE) effects on cognition is via NMDAR-dependent signaling. APOE genotype-specific effects on this pathway were dissected using EFAD-transgenic (Tg) mice (5xFAD mice, that over-express human amyloid-beta (Aβ) via 5...

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Identifiers

PMID: 25871877
DOI: 10.1186/s13024-015-0002-2
PMCID: PMC4391134

Genes

APOE
BDNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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