Article

Polygenic risk for schizophrenia converges on alternative polyadenylation as molecular mechanism underlying synaptic impairment

2024-01-10

Abstract excerpt

Schizophrenia (SCZ) is a genetically heterogenous psychiatric disorder of highly polygenic nature. Correlative evidence from genetic studies indicate that the aggregated effects of distinct genetic risk factor combinations found in each patient converge onto common molecular mechanisms. To prove this on a functional level, we employed a reductionistic cellular model system for polygenic risk by differentiating ind...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: be07b31f-7d20-564f-8fcf-8f6d5d4121d9
DOI: 10.1101/2024.01.09.574815

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Polygenic risk for schizophrenia converges on alternative polyadenylation as molecular mechanism underlying synaptic impairmentDOI 10.1101/2024.01.09.574815Read

Current progress in understanding Schizophrenia using genomics and pluripotent stem cells: A Meta-analytical overviewSemantic proximity Read

Splicing-specific transcriptome-wide association uncovers genetic mechanisms for schizophrenia.Semantic proximity Read

Modeling common and rare genetic risk factors of neuropsychiatric disorders in human induced pluripotent stem cells.Semantic proximity Read

A foundational neuronal protein network model unifying multimodal genetic, transcriptional, and proteomic perturbations in schizophreniaSemantic proximity Read

Non-additive effects of schizophrenia risk genes reflect convergent downstream functionSemantic proximity Read

Single-cell multi-cohort dissection of the schizophrenia transcriptomeSemantic proximity Read

Generation of induced pluripotent stem cells from 8 neurotypical individuals with elevated genetic risk for schizophrenia.Semantic proximity Read

Cell type and condition specific functional annotation of schizophrenia associated non-coding genetic variantsSemantic proximity Read

Mapping genomic loci implicates genes and synaptic biology in schizophrenia.Semantic proximity Read

Ventral forebrain organoids derived from individuals with schizophrenia recapitulate perturbed striatal gene expression dynamics of the donor’s brainsSemantic proximity Read

Integrating rare variant genetics and brain transcriptome data implicates novel schizophrenia putative risk genes.Semantic proximity Read

Multiple genes <i>in cis</i> mediate the effects of a single chromatin accessibility variant on aberrant synaptic development and function in human neuronsSemantic proximity Read