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Article

Splicing-specific transcriptome-wide association uncovers genetic mechanisms for schizophrenia.

American journal of human genetics - 8 Aug 2024

Hervoso Jonatan L, Amoah Kofi, Dodson Jack, Choudhury Mudra, Bhattacharya Arjun, Quinones-Valdez Giovanni, Pasaniuc Bogdan, Xiao Xinshu

Abstract excerpt

Recent studies have highlighted the essential role of RNA splicing, a key mechanism of alternative RNA processing, in establishing connections between genetic variations and disease. Genetic loci influencing RNA splicing variations show considerable influence on complex traits, possibly surpassing those affecting total gene expression. Dysregulated RNA splicing has emerged as a major potential contributor to...

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Identifiers

PMID: 38925119
DOI: 10.1016/j.ajhg.2024.06.001
PMCID: PMC11339621

Genes

VPS45

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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