Article

A foundational neuronal protein network model unifying multimodal genetic, transcriptional, and proteomic perturbations in schizophrenia

2025-05-06

Abstract excerpt

<h4>Summary</h4> Schizophrenia (SCZ) is a complex psychiatric disorder with a diverse genetic landscape, involving common regulatory variants, rare protein-coding mutations, structural genomic rearrangements, and transcriptional dysregulation. A critical challenge in developing rationally designed therapeutics is understanding how these various factors converge to disrupt cellular networks in the human brain, ulti...

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Literature Corpus work: 351034e4-2c32-529f-abe5-a7415ceb3616
DOI: 10.1101/2025.05.02.25326757

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