Article

Current progress in understanding Schizophrenia using genomics and pluripotent stem cells: A Meta-analytical overview

2022-08-22

Abstract excerpt

<h4>ABSTRACT</h4> Schizophrenia (SCZ) is a highly heritable, polygenic neuropsychiatric disease, which disables the patients as well as decreases their life expectancy and quality of life. Common and Rare variants studies on SCZ subjects have provided more than 100 genomic loci that hold importance in the context of SCZ pathophysiology. Transcriptomic studies from clinical samples have informed about the differen...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 78563fc6-b93f-55a4-bd29-a4ceed39319e
DOI: 10.1101/2022.08.18.504397

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Current progress in understanding Schizophrenia using genomics and pluripotent stem cells: A Meta-analytical overviewDOI 10.1101/2022.08.18.504397Read

Ventral forebrain organoids derived from individuals with schizophrenia recapitulate perturbed striatal gene expression dynamics of the donor’s brainsSemantic proximity Read

Generation of induced pluripotent stem cells from 8 neurotypical individuals with elevated genetic risk for schizophrenia.Semantic proximity Read

Concise review: the promise of human induced pluripotent stem cell-based studies of schizophrenia.Semantic proximity Read

Genetics of schizophrenia: A consensus paper of the WFSBP Task Force on GeneticsSemantic proximity Read

Generation and benchmarking of a collection of hiPSC lines from Schizophrenia Patients with Diverse Clinical ProfilesSemantic proximity Read

Cell type and condition specific functional annotation of schizophrenia associated non-coding genetic variantsSemantic proximity Read

Contribution of induced pluripotent stem cell technologies to the understanding of cellular phenotypes in schizophrenia.Semantic proximity Read

The Proteomic Architecture of Schizophrenia Cerebral Organoids Reveals Alterations in GWAS and Neuronal Development FactorsSemantic proximity Read

Genetic studies of schizophrenia: an update.Semantic proximity Read

Publicly available hiPSC lines with extreme polygenic risk scores for modeling schizophreniaSemantic proximity Read

Modeling common and rare genetic risk factors of neuropsychiatric disorders in human induced pluripotent stem cells.Semantic proximity Read

Advances in the understanding of the pathophysiology of schizophrenia and bipolar disorder through induced pluripotent stem cell modelsSemantic proximity Read