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Article

Generation of induced pluripotent stem cells from 8 neurotypical individuals with elevated genetic risk for schizophrenia.

Stem cell research - 1 Sept 2025

Myung Sangho S, Sripathy Srinidhi Rao, Maher Brady J

Abstract excerpt

Schizophrenia (SCZ) is a common and debilitating mental illness characterized by positive and negative symptoms, and impaired cognition. Genome-wide association studies (GWAS) have identified hundreds of genomic regions containing SCZ risk variants. For each individual, a polygenic risk score (PRS) can be derived, which is a metric of genetic susceptibility for SCZ. Here, we report the generation of human induced...

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Identifiers

PMID: 40749619
DOI: 10.1016/j.scr.2025.103791
PMCID: PMC12490714

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