Article

Non-additive effects of schizophrenia risk genes reflect convergent downstream function

2023-03-21

Abstract excerpt

<h4>ABSTRACT</h4> Genetic studies of schizophrenia (SCZ) reveal a complex polygenic risk architecture comprised of hundreds of risk variants, the majority of which are common in the population at-large and confer only modest increases in disorder risk. Precisely how genetic variants with individually small predicted effects on gene expression combine to yield substantial clinical impacts in aggregate is unclear. T...

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Literature Corpus work: 49d2e996-4416-54ac-bc8c-a791d327bcf1
DOI: 10.1101/2023.03.20.23287497

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