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Multiple genes <i>in cis</i> mediate the effects of a single chromatin accessibility variant on aberrant synaptic development and function in human neurons

2021-12-12

Abstract excerpt

Despite hundreds of risk loci from genome-wide association studies of neuropsychiatric disorders, causal variants/genes remain largely unknown. Here, in NEUROG2 -induced human neurons, we identified 31 risk SNPs in 26 schizophrenia (SZ) risk loci that displayed allele-specific open chromatin (ASoC) and were likely to be functional. Editing the strongest ASoC SNP rs2027349 near vacuolar protein sorting 45 homolog...

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Literature Corpus work
cc4f0b48-0bc5-5a96-b635-73de072b9fb5
DOI
10.1101/2021.12.11.472229
Open publication

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Multiple genes <i>in cis</i> mediate the effects of a single chromatin accessibility variant on aberrant synaptic development and function in human neuronsDOI 10.1101/2021.12.11.472229
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