Cell type and condition specific functional annotation of schizophrenia associated non-coding genetic variants

Abstract excerpt

Schizophrenia (SCZ) is a highly polygenic disease and genome wide association studies have identified thousands of genetic variants that are statistically associated with this psychiatric disorder. However, our ability to translate these associations into insights on the disease mechanisms has been challenging since the causal genetic variants, their molecular function and their target genes remain largely unknown...

Topics

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• Genetic Predisposition to Disease
• Genetic Variation
• Genome-Wide Association Study
• High-Throughput Nucleotide Sequencing
• Mice
• Neurons
• Polymorphism, Single Nucleotide
• Schizophrenia

Identifiers and source

Literature Corpus work

b4d6ff33-1d53-5159-96b4-b9b9eae0e0b6

DOI

10.1101/2023.06.27.545266