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Ventral forebrain organoids derived from individuals with schizophrenia recapitulate perturbed striatal gene expression dynamics of the donor’s brains

2022-05-27

Abstract excerpt

<h4>ABSTRACT</h4> Schizophrenia (SCZ) is a brain disorder originating during neurodevelopment with complex genetic and environmental etiologies. Despite decades of clinical evidence of altered striatal function in affected patients, its cellular and molecular underpinnings remain unclear. Here, to explore neurodevelopmental alterations in the striatum associated with SCZ, we established a method for the different...

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Literature Corpus work
6f466778-3d92-51d3-8985-183eb483073a
DOI
10.1101/2022.05.26.493589
Open publication

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Ventral forebrain organoids derived from individuals with schizophrenia recapitulate perturbed striatal gene expression dynamics of the donor’s brainsDOI 10.1101/2022.05.26.493589
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