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Integrating rare variant genetics and brain transcriptome data implicates novel schizophrenia putative risk genes.

Schizophrenia research - 1 Feb 2025

Han Shengtong, Gilmartin Marieke, Sheng Wenhui, Jin Victor X

Abstract excerpt

The etiology of schizophrenia is elusive, in part due to its polygenic nature. Genome-wide association studies (GWAS) have successfully identified hundreds of schizophrenia risk loci, that are pinpointed to over one hundred genes through fine mapping. Besides common variants with relatively small effect size from GWAS, rare variants or ultra rare variants also play a significant role in conferring the...

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PMID: 39919691
DOI: 10.1016/j.schres.2025.01.028

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