Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Modeling common and rare genetic risk factors of neuropsychiatric disorders in human induced pluripotent stem cells.

Schizophrenia research - 1 Nov 2024

Muhtaseb Abdurrahman W, Duan Jubao

Abstract excerpt

Recent genome-wide association studies (GWAS) and whole-exome sequencing of neuropsychiatric disorders, especially schizophrenia, have identified a plethora of common and rare disease risk variants/genes. Translating the mounting human genetic discoveries into novel disease biology and more tailored clinical treatments is tied to our ability to causally connect genetic risk variants to molecular and cellular...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CRISPR-Cas Systems
Share to Gene Editing
Share to Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Induced Pluripotent Stem Cells

Share to Mental Disorders

Share to Risk Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 35459617
DOI: 10.1016/j.schres.2022.04.003
PMCID: PMC9735430

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Modeling common and rare genetic risk factors of neuropsychiatric disorders in human induced pluripotent stem cells.PMID 35459617Read ↗

Opportunities and limitations for studying neuropsychiatric disorders using patient-derived induced pluripotent stem cells.Semantic proximity Read ↗

Publicly available hiPSC lines with extreme polygenic risk scores for modeling schizophreniaSemantic proximity Read ↗

New considerations for hiPSC-based models of neuropsychiatric disorders.Semantic proximity Read ↗

Human-Induced Pluripotent Stem Cell Technology: Toward the Future of Personalized PsychiatrySemantic proximity Read ↗

Current progress in understanding Schizophrenia using genomics and pluripotent stem cells: A Meta-analytical overviewSemantic proximity Read ↗

Modeling developmental neuropsychiatric disorders with iPSC technology: challenges and opportunities.Semantic proximity Read ↗

Functional characterization of gene regulatory elements and neuropsychiatric disease-associated risk loci in iPSCs and iPSC-derived neuronsSemantic proximity Read ↗

Generation of induced pluripotent stem cells from 8 neurotypical individuals with elevated genetic risk for schizophrenia.Semantic proximity Read ↗

Transcriptional signatures of schizophrenia in hiPSC-derived NPCs and neurons are concordant with signatures from post mortem adult brainsSemantic proximity Read ↗

Contribution of induced pluripotent stem cell technologies to the understanding of cellular phenotypes in schizophrenia.Semantic proximity Read ↗

Modeling neuronal consequences of autism-associated gene regulatory variants with human induced pluripotent stem cells.Semantic proximity Read ↗

Ventral forebrain organoids derived from individuals with schizophrenia recapitulate perturbed striatal gene expression dynamics of the donor’s brainsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.