Article

Lamina and Heterochromatin Direct Chromosome Organisation in Senescence and Progeria

2018-11-13

Abstract excerpt

Lamina-associated domains (LADs) cover a large part of the human genome and are thought to play a major role in shaping the nuclear architectural landscape. Here, we use simulations based on concepts from polymer physics to dissect the roles played by heterochromatin- and lamina-mediated interactions in nuclear organisation. Our model explains the conventional organisation of heterochromatin and euchromatin in gro...

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Literature Corpus work: bdfa316c-38fa-51fe-a3d2-042d1ee856b9
DOI: 10.1101/468561

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