Article

Phase Behavior and Dissociation Kinetics of Lamins in a Polymer Model of Progeria

2024-10-24

Abstract excerpt

One of the key structural proteins in the eukaryotic cell nucleus is lamin. Lamins can assemble into a two-dimensional protein meshwork at the nuclear periphery, referred to as the nuclear lamina, which provides rigidity and shape to the nucleus. Mutations in lamin proteins that affect the structure of the nuclear lamina underlie laminopathic diseases, including Hutchinson–Gilford Progeria Syndrome (HGPS). Experim...

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Literature Corpus work: 55275f81-cab3-5115-836d-5ba4e866ff5c
DOI: 10.1101/2024.10.21.619497

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