Article

The compartmental polarization of interphase human chromosomes within the nucleus: A mechanism for transcriptional regulation of large chromosomes

2026-08-25

Abstract excerpt

The structure and dynamics of individual chromosomes are significantly modulated by their local environment within the nucleus. It has long been established that heterochromatin (B compartment loci) associates with the lamina meshwork that lines the inner nuclear envelope. However, the extent to which these interactions perturb the chromosomal organization within a territory remains unclear. Using computer simulat...

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Literature Corpus work: 15e10f0a-e66b-50fb-ba99-93c858df1407
DOI: 10.64898/2026.08.21.746281

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