Article

Kinetochore life histories reveal the origins of chromosome mis-segregation and correction mechanisms

2021-03-31

Abstract excerpt

<h4>ABSTRACT</h4> Chromosome mis-segregation during mitosis leads to daughter cells with deviant karyotypes (aneuploidy) and an increased mutational burden through chromothripsis of mis-segregated chromosomes. The rate of mis-segregation and the aneuploidy state are hallmarks of cancer and linked to cancer genome evolution. Errors can manifest as “lagging chromosomes” in anaphase, although the mechanistic origins...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 4db3f821-be8f-5325-b4a6-4654e54de811
DOI: 10.1101/2021.03.30.436326

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Kinetochore life histories reveal the origins of chromosome mis-segregation and correction mechanismsDOI 10.1101/2021.03.30.436326Read

Measuring and modeling the dynamics of mitotic error correctionSemantic proximity Read

Non-Random Mis-Segregation of Human ChromosomesSemantic proximity Read

Bayesian data driven modelling of kinetochore dynamics: space-time organisation of the human metaphase plateSemantic proximity Read

Computational modelling and near-complete kinetochore tracking reveal how chromosome dynamics during cell division are co-ordinated in space and timeSemantic proximity Read

An anaphase surveillance mechanism prevents micronuclei formation from mitotic errorsSemantic proximity Read

Misaligned chromosomes that satisfy the spindle assembly checkpoint are a strong predictor of micronuclei formation in dividing cancer cellsSemantic proximity Read

Ensemble-level organization of human kinetochores and evidence for distinct tension and attachment sensorsSemantic proximity Read

Double-checking chromosome segregationSemantic proximity Read

Kinetochore Malfunction in Human Pathologies.Semantic proximity Read

Structural plasticity of the living kinetochore.Semantic proximity Read

Human genetic variations reveal Chromosomal Instability aiding Variants (CIVa) in kinetochore-microtubule associated proteinsSemantic proximity Read

Lamina and Heterochromatin Direct Chromosome Organisation in Senescence and ProgeriaSemantic proximity Read