Article

Studying the cellular basis of small bowel enteropathy using high-parameter flow cytometry in mouse models of primary antibody deficiency

2024-01-29

Abstract excerpt

<h4>Background</h4> Primary immunodeficiencies are heritable defects in immune system function. Antibody deficiency is the most common form of primary immunodeficiency in humans, can be caused by abnormalities in both the development and activation of B cells, and may result from B-cell-intrinsic defects or defective responses by other cells relevant to humoral immunity. Inflammatory gastrointestinal complication...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: bdf5e66a-bc8c-59e4-86c8-f822e7e3312a
DOI: 10.1101/2024.01.25.577009

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Studying the cellular basis of small bowel enteropathy using high-parameter flow cytometry in mouse models of primary antibody deficiencyDOI 10.1101/2024.01.25.577009Read

Hyperactivated PI3Kδ promotes self and commensal reactivity at the expense of optimal humoral immunity.Semantic proximity Read

Single-cell profiling of immune system alterations in lymphoid, barrier and solid tissues in aged mice.Semantic proximity Read

Variations in the germinal center response revealed by genetically diverse mouse strains.Semantic proximity Read

A pipeline to unravel complexity in human peripheral blood B cell subsets through multiomic cellular indexing of transcriptomes and epitopes by sequencing (CITE-seq) analysesSemantic proximity Read

Heterogeneous immune cell composition in patients with combined immunodeficiency.Semantic proximity Read

High-throughput phenotyping reveals expansive genetic and structural underpinnings of immune variationSemantic proximity Read

Targeting the APRIL-BAFF axis in IgA nephropathy: preclinical insights from influenza challenge and single-cell spatial profilingSemantic proximity Read

Multi-omic profiling of human antibody-secreting cells reveals diverse subsets sustain durable humoral immunitySemantic proximity Read

Mucosal deficiency of mitochondria-driven humoral immunity is linked to Crohn’s DiseaseSemantic proximity Read

Complex subsets but redundant clonality after B cells egress from spontaneous germinal centersSemantic proximity Read

Single cell transcriptome atlas of immune cells in human small intestine and in celiac diseaseSemantic proximity Read

Investigating the phenotype and function of tissue-resident B cells in mouse and human non-lymphoid organsSemantic proximity Read