Hyperactivated PI3Kδ promotes self and commensal reactivity at the expense of optimal humoral immunity.

doi:10.1038/s41590-018-0182-3

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Article

Hyperactivated PI3Kδ promotes self and commensal reactivity at the expense of optimal humoral immunity.

Nature immunology - 1 Sept 2018

Preite Silvia, Cannons Jennifer L, Radtke Andrea J, Vujkovic-Cvijin Ivan, Gomez-Rodriguez Julio, Volpi Stefano, Huang Bonnie, Cheng Jun, Collins Nicholas, Reilley Julie, Handon Robin, Dobbs Kerry, Huq Lutfi, Raman Indu, Zhu Chengsong, Li Quan-Zhen, Li Ming O, Pittaluga Stefania, Uzel Gulbu, Notarangelo Luigi D, Belkaid Yasmine, Germain Ronald N, Schwartzberg Pamela L

Abstract excerpt

Gain-of-function mutations in the gene encoding the phosphatidylinositol-3-OH kinase catalytic subunit p110δ (PI3Kδ) result in a human primary immunodeficiency characterized by lymphoproliferation, respiratory infections and inefficient responses to vaccines. However, what promotes these immunological disturbances at the cellular and molecular level remains unknown. We generated a mouse model that recapitulated...

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PMID: 30127432
DOI: 10.1038/s41590-018-0182-3
PMCID: PMC6140795

Genes

FOXO1
ICOS

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