Article
Single-cell profiling of immune system alterations in lymphoid, barrier and solid tissues in aged mice.
Nature aging - 1 Jan 2022
Krishnarajah Sinduya, Ingelfinger Florian, Friebel Ekaterina, Cansever Dilay, Amorim Ana, Andreadou Myrto, Bamert David, Litscher Gioana, Lutz Mirjam, Mayoux Maud, Mundt Sarah, Ridder Frederike, Sparano Colin, Stifter Sebastian Anton, Ulutekin Can, Unger Susanne, Vermeer Marijne, Zwicky Pascale, Greter Melanie, Tugues Sonia, De Feo Donatella, Becher Burkhard
Abstract excerpt
Aging exerts profound and paradoxical effects on the immune system, at once impairing proliferation, cytotoxicity and phagocytosis, and inducing chronic inflammation. Previous studies have focused on individual tissues or cell types, while a comprehensive multisystem study of tissue-resident and circulating immune populations during aging is lacking. Here we reveal an atlas of age-related changes in the abundance...
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