Article

Mucosal deficiency of mitochondria-driven humoral immunity is linked to Crohn’s Disease

2025-04-23

Abstract excerpt

<title>Abstract</title> <p> Secretory IgA (SIgA) is critical for maintaining the intestinal barrier. A dysregulated B-cell compartment and altered Ig secretion have been well documented in Crohn’s disease (CD) patients, although their origin is unknown. To unravel the role of mucosal humoral immunity in CD pathogenesis, we in-depth phenotyped colonic plasma cell (PC) differentiation in CD at the single-cell leve...

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Literature Corpus work: 0bf43a3a-3f91-5bd6-906e-fc3be29ae7bf
DOI: 10.21203/rs.3.rs-6463867/v1

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