Article
High-throughput phenotyping reveals expansive genetic and structural underpinnings of immune variation
2019-07-02
Abstract excerpt
<h4>ABSTRACT</h4> By developing a high-density murine immunophenotyping platform compatible with high-throughput genetic screening, we have established profound contributions of genetics and structure to immune variation. Specifically, high-throughput phenotyping of 530 knockout mouse lines identified 140 monogenic “hits” (>25%), most of which had never hitherto been implicated in immunology. Furthermore, they we...
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Identifiers and source
- Literature Corpus work
- c85cb485-c277-59c1-a068-830e7a02b7e5
- DOI
- 10.1101/688010