Article

Complex subsets but redundant clonality after B cells egress from spontaneous germinal centers

2022-06-23

Abstract excerpt

<h4>ABSTRACT</h4> Affinity matured self-reactive antibodies are found in autoimmune diseases like systemic lupus erythematous. Here we used fate-mapping reporter mice and single cell transcriptomics coupled to antibody repertoire analysis to characterize the post-germinal center (GC) B cell compartment in a new mouse model of autoimmunity. Antibody secreting cells (ASCs) and memory B cells (MemBs) from spontaneou...

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Literature Corpus work: ea3dba50-5d93-5b4e-85fb-d2864e88ff7f
DOI: 10.1101/2022.06.21.496939

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