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A pipeline to unravel complexity in human peripheral blood B cell subsets through multiomic cellular indexing of transcriptomes and epitopes by sequencing (CITE-seq) analyses

2025-01-29

Abstract excerpt

<title>Abstract</title> <p>Classifying heterogeneous human B cells into discrete subsets based on surface phenotype alone remains a major challenge. We discovered a mouse splenic IgM<sup>+</sup>IgD<sup>low/−</sup> B cell subset (BD<sub>L</sub>) that induces proliferation of CD4<sup>+</sup>Foxp3<sup>+</sup> T regulatory cells, making them a therapeutic target for autoimmunity. Because they are rare and lack suffic...

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Literature Corpus work
0ab6a759-c801-52db-8f24-7438fe63d7de
DOI
10.21203/rs.3.rs-5634279/v1
Open publication

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A pipeline to unravel complexity in human peripheral blood B cell subsets through multiomic cellular indexing of transcriptomes and epitopes by sequencing (CITE-seq) analysesDOI 10.21203/rs.3.rs-5634279/v1
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