Article

Targeting the APRIL-BAFF axis in IgA nephropathy: preclinical insights from influenza challenge and single-cell spatial profiling

2026-05-06

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> APRIL and BAFF are TNF superfamily cytokines that regulate B-cell development, survival, and antibody production, and are emerging therapeutic targets for IgA nephropathy (IgAN). Selective APRIL and dual APRIL/BAFF inhibitors both reduce IgA and proteinuria in IgAN clinical trials, but whether their broader immunological consequences differ has not been systematically charac...

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Literature Corpus work: b0e0e22b-06e3-538f-8cd3-a79ee89e800e
DOI: 10.64898/2026.05.01.722321

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