Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Role of Histone Methyltransferase SETDB1 in Normal and Malignant Hematopoiesis

4 Jun 2025

Abstract excerpt

SET domain bifurcated histone methyltransferase 1 (SETDB1) is a histone H3 lysine 9 (H3K9) methyltransferase, functioning in transcriptional silencing of the transposable elements (TEs), endogenous retroviruses (ERVs), interferon-stimulated genes (ISGs), and immune cell-related molecules. SETDB1 collaborates with cofactors such as ATF7IP and TRIM28 and functions in concert with DNA methylation to maintain gene...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Myeloid Leukemia Research
Share to Epigenetics and DNA Methylation
Share to Immune Cell Function and Interaction

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40464268
DOI: 10.1111/cas.70116

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Role of Histone Methyltransferase SETDB1 in Normal and Malignant HematopoiesisPMID 40464268Read ↗

The H3K4 methyltransferase Setd1b is essential for hematopoietic stem and progenitor cell homeostasis in miceSemantic proximity Read ↗

SETDB1 mediated histone H3 lysine 9 methylation suppresses MLL-fusion target expression and leukemic transformationSemantic proximity Read ↗

Histone methyltransferase SETDB1 safeguards mouse fetal hematopoiesis by suppressing activation of cryptic enhancersSemantic proximity Read ↗

Roles of SETD2 in Leukemia—Transcription, DNA-Damage, and BeyondSemantic proximity Read ↗

Setdb1 maintains hematopoietic stem and progenitor cells by restricting the ectopic activation of nonhematopoietic genesSemantic proximity Read ↗

The Role of Nuclear Receptor-Binding SET Domain Family Histone Lysine Methyltransferases in Cancer.Semantic proximity Read ↗

Targeting human SET1/MLL family of proteinsSemantic proximity Read ↗

SETting the Stage for Cancer Development: SETD2 and the Consequences of Lost Methylation.Semantic proximity Read ↗

Epigenetic regulation in hematopoiesis and its implications in the targeted therapy of hematologic malignanciesSemantic proximity Read ↗

ADAR1 is essential for the maintenance of hematopoiesis and suppression of interferon signalingSemantic proximity Read ↗

Epigenetics of hematopoiesis and hematological malignancies.Semantic proximity Read ↗

Epigenetic silencing of transposable elements by IRF2BP2 is a selective dependency of myeloid leukemiaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.