Article

Dysfunction of a SET3-like complex underlies a family of related neurological disorders

2025-05-30

Abstract excerpt

TBLR1 is a subunit of the NCoR corepressor complex that is mutated in a range of neurodevelopmental disorders. Here, we report that TBLR1 functions as a molecular scaffold that physically connects ANKRD11 and SETD5 – two of the most frequently mutated proteins in neurodevelopmental disorders – and links them to the rest of the NCoR complex. The resulting assembly resembles the yeast SET3 complex (SET3C) – a transc...

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Literature Corpus work: f81947d3-ce19-5f2e-ae8c-9766356a8b33
DOI: 10.1101/2025.05.30.657039

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