Article
ZMYM3 mutations modulate histone acetylation and cooperate with NOTCH1 mutations in chronic lymphocytic leukemia.
Blood advances - 11 Aug 2026
Rodríguez-Sánchez Alberto, Pérez-Carretero Claudia, Corchete-Sánchez Luis A, Miguel-García Cristina, Santos-Mínguez Sandra, Villaverde-Ramiro Ángela, Dávila Julio, García de Coca Alfonso, Galende Josefina, Juanes-Velasco Pablo, Fuentes Manuel, Benito-Sánchez Rocío, Rodríguez-Vicente Ana E, Quijada-Álamo Miguel, Hernández Rivas Jesús María
Abstract excerpt
ABSTRACT: ZMYM3 mutations have been recurrently identified in patients with chronic lymphocytic leukemia (CLL) at diagnosis. However, their clinical relevance and functional implications remain poorly defined. In this study, we comprehensively characterize the clinical and translational impact of ZMYM3 mutations in CLL. Next-generation sequencing analyses of 487 CLL patients identified 32 ZMYM3 variants, which...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.