Article

Heterochromatin fidelity is a therapeutic vulnerability in lymphoma and other human cancers

2025-02-05

Abstract excerpt

<h4>ABSTRACT</h4> Genes involved in the regulation of chromatin structure are frequently disrupted in cancer, contributing to an aberrant transcriptome and phenotypic plasticity. Yet, therapeutics targeting mutant forms of chromatin-modifying enzymes have yielded only modest clinical utility, underscoring the difficulty of targeting the epigenomic underpinnings of aberrant gene regulatory networks. Here, we sough...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c6c4217a-e7a9-5ad3-9281-80c93324aef4
DOI: 10.1101/2025.01.31.635709

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Heterochromatin fidelity is a therapeutic vulnerability in lymphoma and other human cancersDOI 10.1101/2025.01.31.635709Read

AEBP2-Directed H3K27me2 Defines a Specific Vulnerability in EZH2-mutant LymphomaSemantic proximity Read

Enhancer and metabolic rewiring by KMT2C-COMPASS or KMT2D-COMPASS family loss in cancer creates druggable vulnerabilities.Semantic proximity Read

Follicular lymphoma, a B cell malignancy addicted to epigenetic mutations.Semantic proximity Read

Chromatin Mechanisms Driving Cancer.Semantic proximity Read

Mutation of chromatin modifiers; an emerging hallmark of germinal center B-cell lymphomas.Semantic proximity Read

Epigenetic targeting of PGBD5-dependent DNA damage in SMARCB1-deficient sarcomasSemantic proximity Read

Genetic aberrations in chromatin factors are pervasive, mutually exclusive, associated with a high mutational burden and improved response to checkpoint immunotherapy in cancerSemantic proximity Read

Genomic characterization of genes encoding histone acetylation modulator proteins identifies therapeutic targets for cancer treatment.Semantic proximity Read

The genomic landscape of mantle cell lymphoma is related to the epigenetically determined chromatin state of normal B cells.Semantic proximity Read

Histone H1 Mutations in Lymphoma: A Link(er) between Chromatin Organization, Developmental Reprogramming, and Cancer.Semantic proximity Read

Combined EZH2 Inhibition and IKAROS Degradation Leads to Enhanced Antitumor Activity in Diffuse Large B-cell LymphomaSemantic proximity Read

The many layers of epigenetic dysfunction in B-cell lymphomas.Semantic proximity Read