Article
The Role of Nuclear Receptor-Binding SET Domain Family Histone Lysine Methyltransferases in Cancer.
Cold Spring Harbor perspectives in medicine - 1 Jun 2017
Bennett Richard L, Swaroop Alok, Troche Catalina, Licht Jonathan D
Abstract excerpt
The nuclear receptor-binding SET Domain (NSD) family of histone H3 lysine 36 methyltransferases is comprised of NSD1, NSD2 (MMSET/WHSC1), and NSD3 (WHSC1L1). These enzymes recognize and catalyze methylation of histone lysine marks to regulate chromatin integrity and gene expression. The growing n...
Topics
- Animals
- Cell Transformation, Neoplastic
- Gene Expression
- Histone-Lysine N-Methyltransferase
- Histones
- Humans
- Mice
- Mutation
- Neoplasms
- PR-SET Domains
- Protein Processing, Post-Translational
- Receptors, Cytoplasmic and Nuclear
- Repressor Proteins