Article

Single-cell transcriptomic atlas of the human substantia nigra in Parkinson’s disease

2022-03-27

Abstract excerpt

Parkinson’s disease (PD) is a common and complex neurodegenerative disorder. Loss of neuromelanin-containing dopaminergic (DA) neurons in the substantia nigra (SN) is a hallmark of PD neuropathology; the etiology of PD remains unclear. Single-cell (-nucleus) RNA sequencing (sc or snRNAseq) has significantly advanced our understanding of neurodegenerative diseases including Alzheimer’s, but limited progress has bee...

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Literature Corpus work: bdaae6f8-39eb-5576-84a3-a9dcd3ecdc6b
DOI: 10.1101/2022.03.25.485846

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