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A single-cell atlas of the human substantia nigra reveals cell-specific pathways associated with neurological disorders

21 Aug 2020

Abstract excerpt

We describe a human single-nuclei transcriptomic atlas for the substantia nigra (SN), generated by sequencing approximately 17,000 nuclei from matched cortical and SN samples. We show that the common genetic risk for Parkinson's disease (PD) is associated with dopaminergic neuron (DaN)-specific gene expression, including mitochondrial functioning, protein folding and ubiquitination pathways. We identify a...

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PMID: 32826893
DOI: 10.1038/s41467-020-17876-0

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