Article

Integrated profiling of single cell epigenomic and transcriptomic landscape of Parkinson’s disease mouse brain

2020-02-04

Abstract excerpt

Parkinson’s disease (PD) is a neurodegenerative disease leading to the impairment of execution of movement. PD pathogenesis has been largely investigated, but either restricted in bulk level or at certain cell types, which failed to capture cellular heterogeneity and intrinsic interplays among distinct cell types. To overcome this, we applied single-nucleus RNA-seq and single cell ATAC-seq on cerebellum, midbrain...

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Literature Corpus work: 8b5e3e63-ab5b-5ae6-8ead-74ddcb01050e
DOI: 10.1101/2020.02.04.933259

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