Article

A human single-cell atlas of the Substantia nigra reveals novel cell-specific pathways associated with the genetic risk of Parkinson’s disease and neuropsychiatric disorders

2020-04-30

Abstract excerpt

We describe a human single-nuclei transcriptomic atlas for the Substantia nigra ( SN) , generated by sequencing ~ 17,000 nuclei from matched cortical and SN samples. We show that the common genetic risk for Parkinson’s disease ( PD ) is associated with dopaminergic neuron ( DaN )-specific gene expression, including mitochondrial functioning, protein folding and ubiquitination pathways. We identify a distinct...

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Literature Corpus work: 9a3e15e9-0351-58d0-92de-7038a9d09619
DOI: 10.1101/2020.04.29.067587

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