Article

Single-cell sequencing of the human midbrain reveals glial activation and a neuronal state specific to Parkinson’s disease

2020-09-30

Abstract excerpt

Parkinson’s disease (PD) etiology is associated with genetic and environmental factors that lead to a loss of dopaminergic neurons. However, the functional interpretation of PD-associated risk variants and how other midbrain cells contribute to this neurodegenerative process are poorly understood. Here, we profiled >41,000 single-nuclei transcriptomes of postmortem midbrain tissue from 6 idiopathic PD (IPD) patien...

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Literature Corpus work: 6f227a58-f4fa-5f3f-a24f-7fae1e007e75
DOI: 10.1101/2020.09.28.20202812

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