Article

A deep cellular atlas of the human ventral substantia nigra in Parkinson’s identifies a genetic and molecular overlap with insulin resistance

2025-05-28

Abstract excerpt

Parkinson’s disease (PD) is a complex neurodegenerative disorder characterised by selective neuronal loss. We integrate deep full-length single-nuclei sequencing of the human substantia nigra with novel genome-wide association studies (GWAS) identifying genetic and cellular drivers of PD. Genetic risk converges on AGTR1+ dopaminergic neurons and perineuronal oligodendrocytes (pODCs), both reduced in PD, as well as...

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Literature Corpus work: 2962bda5-fb16-56d7-af99-2be0b74c14a8
DOI: 10.1101/2025.05.28.25328401

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