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Cell-Type-Resolved Transcriptional Remodelling in Parkinson’s Disease Substantia Nigra: An Integrated Framework Implicates NPAS3 and BNC2 Regulatory Subnetworks in Dopaminergic Neurons and Glial Subpopulations

2026-06-05

Abstract excerpt

<h4>Background</h4> Parkinson’s disease (PD) is a second most common progressive neurological disorder that is pathologically characterized by the loss of dopaminergic neurons within the substantia nigra (SN). However, disease progression probably involves coordinated changes across both neuronal and glial cell populations. Although single-nucleus RNA-seq resolved cell-type-specific transcriptional profiling, dif...

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Literature Corpus work: bd9f9206-2bcd-5ad5-b28f-7242b7f19a0a
DOI: 10.64898/2026.06.04.26354575

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