Article

Molecular and cellular signatures differentiate Parkinson’s disease from Parkinson’s disease with dementia

2025-03-04

Abstract excerpt

Parkinson’s disease (PD) affects millions of people worldwide, and up to 40% of these patients develop dementia, profoundly affecting their quality of life. Whether Parkinson’s disease dementia (PDD) simply represents a late stage of PD or constitutes a distinct neurodegenerative process remains unresolved. To clarify this, we generated the largest single nuclear transcriptomic atlas of PD and PDD to date—almost o...

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Literature Corpus work: 987680d0-c2c7-52a9-88f6-b0b4aa7dc6a9
DOI: 10.1101/2025.03.04.641379

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