Article

A molecular atlas of cell-type specific signatures in the parkinsonian striatum

2025-09-10

Abstract excerpt

<h4>Summary</h4> The progressive degeneration of dopaminergic projections to the striatum is a key disease mechanism in Parkinson’s disease (PD). To define the cellular landscape in the parkinsonian striatum, we mapped the cell-type specific transcriptional landscape in early and progressive PD mouse models and in human PD stages. Our analyses revealed substantial transcriptomic changes across both neuronal and g...

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Literature Corpus work: 567d2d5e-bdc8-5b0e-9287-4d5a9182afa5
DOI: 10.1101/2025.09.09.675138

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